ACR122U’s are pretty well supported, moreso than a PM3 for sure.
Just note they’re not the “best” - get a Feitian if you can. They’re not significantly more expensive but they provide proper extended APDU support and proper wait timeouts - see my post (Fix for ACR122U Time Extension) for a workaround on the ACR122U. Not much help if you’re doing random generic commands that could at any point time the reader out, though.