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I do I wear a ton of frankincense myrrh and cinnamon saffron and rose oil everyday I anoint my tallot and I dip my robes in my miraculous wine and firmented wines and spikenard.

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Valeriana jatamansi

N. jatamansi is a perennial herb about 16–50cm tall with a long stout, fragrant rhizome (Fig. 1).

From: Reference Module in Earth Systems and Environmental Sciences, 2021

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Nardostachys jatamansi- An Endemic Himalayan Species in Peril

Harsh Kumar Chauhan, in Reference Module in Earth Systems and Environmental Sciences, 2021

Introduction

Nardostachys jatamansi (D. Don) DC is a rhizomatous perennial herb distributed endemically at an altitude of 3000–5000 m asl in the Himalayas (Airi et al., 2000; Chauhan and Nautiyal, 2005). This species is extensively harvested for its rhizomes/roots which have high medicinal value. The species is ethnobotanically known for the treatment of nervous, digestive, circulatory, respiratory, urinary, stomach, and reproductive disorders, and to cure cough, fever, headache, food poisoning, cholera, stomach disorders, intestinal worms, joint pain, rheumatism, stomach disorders, and jaundice (Kaur et al., 2020). N. jatamansi finds extensive uses in the pharmaceutical industry as it exhibits anti-hyperglycemic, anti-inflammatory, anti-diabetic activities, anti-cancer activity, nootropic effect against dementia and Alzheimer’s disease (Dhiman and Bhattacharya, 2020). The species is over-exploited and is critically endangered (Ved et al., 2015). Factors such as high trade value, endemic nature, specific habitat requirements, deforestation, and over-grazing, etc. are responsible for its declining populations. This chapter provides an overview of the biology, threats, and conservation of N. jatamansi .

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Valeriana sp.: The Role in Ameliorating High-Altitude Ailments

Jigni Mishra, Kshipra Misra, in Management of High Altitude Pathophysiology, 2018

4.2 Description of the Plant

V. wallichii DC (henceforth referred to as VW), also known as Valeriana jatamansi Jones is a small, perennial, pubescent herb belonging to the family Valerianaceae , order Dipsacales , that is 14–45 cm tall (Fig. 4.1). Commonly referred to as Indian valerian or tagar-ganthoda, VW has horizontal, thick rootstock with thick descending fibrous roots (Singh et al., 2013). The roots are usually yellowish brown in color, measuring 1.5–7 cm long and 1–2 mm high, and constitute one of the medicinally most important parts of the VW plant (Fig. 4.2). The roots have piliferous layer of papillosed cells, some of which develop into root hairs. Exodermis is a single layer of quadrangular to polygonal cells with suberized walls, containing globules of volatile oil. The root cortex is parenchymatous with several starch granules. Cells in the outermost layer also have abundant globules of volatile oil (Mhaske et al., 2011). The rhizome is yellowish to brownish, subcylindrically shaped; having a length of 4–7 cm and thickness of about 1 cm. Leaves are radical, persistent, stalked, cordate-ovate, acute, and toothed. Flowers of VW are pinkish-white or whitish in color, arranged in a terminal corymb having an approximate diameter of 3–8 cm. The flowers are unisexual, with male and female flowers on different plants. Fruits of VW plant are small and smooth, sometimes hairy. VW odor is typically valerianaceous and taste is largely bitter (Bos et al., 1997; Devi and Rao, 2014).

Fig. 4.1

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Fig. 4.1. Valeriana wallichii herb thriving in Himalayan valleys.

Fig. 4.2

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Fig. 4.2. Roots of Valeriana wallichii herb.

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Herbal Formulations and Their Bioactive Components as Dietary Supplements for Treating Rheumatoid Arthritis

Palani Dinesh, Mahaboobkhan Rasool, in Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases (Second Edition), 2019

3.2 Majoon Ushba

Majoon ushba (MU) is an Unani-based polyherbal formulation derived from 14 plant species, including Pterocarpus santalinus , Cassia angustifolia , Smilax china , Santalum album , Roasa damascene , Piper chaba , Cinnamomim zeylaricum , Borage offinialis , Custa reflexa , Polypodium vulgae , Smilax officinalis , Nardostachys jatamansi , Terminalia chebula , and Terminalia belerica. 22 It is an extensively used Indian unani formulation that is used to treat inflammatory conditions with minimal or no side effects.23 The bioactive components of this polyherbal derivative are comprised of ferulic acid, p-coumaric acid, morin, vanillic acid, gallic acid, catechin, and quercetin, which are well established as possessing antioxidant and antiinflammatory activity.24,25 However, much less scientific evidence is available to elucidate its effects in treating an autoimmune disorder such as RA.

It has been recently identified that MU suppresses clinical manifestations in AIA rats through the suppression of NFĪŗB and AP-1 transcription factors. Furthermore, MU reduces bone resorption via the suppression of receptor activator of nuclear factor kappa B ligand (RANKL) and upregulation of osteoprotegerin (OPG).26 MU has also been substantiated to reduce the proliferation of fibroblast-like synoviocytes (FLS) through the attenuation of ERK/MAPKs, resulting in the suppression of inflammatory cytokines and chemokines.27

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Characterization Techniques for Herbal Products

Rakhee, … Kshipra Misra, in Management of High Altitude Pathophysiology, 2018

9.2 Characteristics of HA Himalayan Medicinal Plants

The HA Himalayan regions, until recently, were less explored because of difficulties with accessibility and harsh climatic conditions. In the last few years, however, HA medicinal plants and herbs have gained substantial interest among researchers because of their unique and rich content of numerous bioactive constituents (Theis and Lerdau, 2003). Considering the abundance of medicinally important pharmacological compounds present in HA herbs, around 70%–80% of the world’s population depend on drug preparations from such herbal sources to treat several health problems.

Some of these pharmacological constituents along with their bioactivities are summarized in Table 9.1.

Table 9.1. High-Altitude Medicinal Plants With Their Active Components, Distribution, and Therapeutic Activities

Medicinal Plants Images Active Components Distribution Therapeutic Activities References
Aconitum heterophyllum Aconitine, benzoylmesaconine, mesaconitine, hypaconitine, hetidine, atidine Uttaranchal, Himachal Pradesh, Sikkim (common in the subalpine and alpine zones of Himalayas at altitudes between 1800 and 4500) Antiperiodic, anodyne, antidiabetic, antipyretic, narcotic, powerful sedative Kaul (1997); http://senthuherbals.blogspot.in/2015/03/aconitum-heterophyllumadhividayam.html?view=snapshot
Acorus calamus Myristic, palmitic, stearic, oleic, linoleic, arachidic, asarone, beta-asarone, (āˆ’)-4-terpineol, 2-allyl-5-ethoxy-4-methoxyphenol, epieudesmin, lysidine, (āˆ’)-spathulenol, borneol, furyl ethyl ketone, nonanoic acid, 2,2,5,5-tetramethyl-3-hexanol, bornyl acetate Uttaranchal, Himachal Pradesh (found throughout the Indian Himalayas up to 6000 m and in Sri Lanka) Intellect promoting, thermogenic, alexeteric Balakumbahan et al. (2010)
Artemisia annua Linn. Coumarin, apigenin, artemetin, clilorogenic acid, quinic acid, coumaric acid, myricetin, kaempferol, rutin, isorhanetin, eupatin, axillarin Himachal Pradesh Antimalarial, antibacterial, anticancer, antioxidant activity, antiasthma Gupta et al. (2009), Chen et al. (2003), Kale et al. (2008); Artemisia annua - Wikipedia
Asparagus racemosa Steroidal saponins, shatavaroside A, shatavaroside B, filiasparoside C, shatavarins, immunoside, 8-methoxy-5,6,4′-trihydroxyisoflavone 7-O-β-d-glucopyranoside Arunachal Pradesh, Meghalaya Antiseptic, dysentry, diuretic Hayes et al. (2008), Saxena and Chourasia (2001); Asparagus racemosus - Wikipedia
Atropa belladona Linn. Atropine, I-hyoscyamine, I-hyoscine, 1-arginine, I-ornithine, scopolamine, hyoscyamine Assam (District of Goalpara) Antiinflammatory, anticholinergic/antispasmodic action, mild sedative Mathews et al. (1990); Kaul (2010); Basumatary et al. (2004); Atropa belladonna - Wikipedia
Bergenia ligulata Bergenin, tannic acid, gallic acid, stigmesterol, P-sitosterol, catechin, (+)-afzelechin, 1, 8-cineole, isovalaric acid, (+)-(6 S )-parasorbic acid, arbutin, phytol, caryophyllene, damascenone, β-eudesmol, 3-methyl-2-buten-l-ol, ( Z )-asarone, terpinen-4-ol, paashaanolactone Uttaranchal, Arunachal Pradesh, Meghalaya, Himachal Pradesh (found throughout Himalayas, Kashmir and Khasi Hills of Assam) Pulmonary affections, dysentery, antiinflammatory, antidiuretic, eye disease, cut and burns, fever, antidiabetic, astringent, cardiotonic, wound healer, antipyretic, hepatoprotective, anticancer, antiprotozoal, antiinflammatory Pashanbheda(Bergenia ligulata) A Great Herb To Dissolve Kidney Stone & More - bimbima; Verma et al. (2014)
Cinchona ledgeriana Quinine, anthraquinones, purpurin, anthragallol-1,2-dimethylether, anthragallol-1,3-dimethylether, rubiadin, 1-hydroxy-2-hydroxymethylanthraquinone, 1-hydroxy-2-methylanthraquinone, morindone-5-methylether, anthraquinones Meghalaya Antispasmodic, astrigent, antibacterial, antimalarial Maehara et al. (2013); https://books.google.co.in/books?id=g2Pt45ETJNnkC&lpg=PA297&ots = bv8FvfuJ3i&dq = anthraquinones%20%20in%20natural%20Cinchona%201edgeriana&pg = PA297#v = onepage&q = anthraquinones%20%20in%20natural%20Cinchona% 20ledgeriana&f = false; Wijnsma et al. (1985)
Colchicum luteum Baker Colchicine, cornigerine, purpurin, anthragallol-1,2-dimethylether, anthragallol-1,3-dimethylether, rubiadin, 1-hydroxy-2-hydroxymethylanthraquinone, 1-hydroxy-2-methylanthraquinone Ladakh, Kargil, Kashmir to Chamba (Suru valley) Antigout, stomachache Singh and Chaurasia (1998); Catalogue of Life - 2014 Annual Checklist :: Search all names details/species/id/9766304
Cordyceps sp. Cordycepin, adenosine, cytosine, thymine, adenine, guanine, uracil, hypoxanthine, uridine-5-mono-phosphate, adenosine-5-monophosphate, guanosine-5-monophosphate Arunachal Pradesh, Himachal Pradisesh, Uttarakhnnd, Sikkim Antioxidant, antitumor, anti-inflammatory, anticancer activity, immunomodulatory, antifibrotic, antidiabetic, antiarteriosclerosis, radioprotective activity antithrombotic activity Rakhee et al. (2016); Mamta et al. (2015)
Curcuma sp. Curcumin, curcuminoids, 4-hydroxybenzaldehyde Tripura (Jampui Hill, Suryamaninagar, Baramura hill) Anticancer activity, cytotoxicity, Bis-demethoxycurcumin Tripathi et al. (2002), Saha et al. (2016), Kuttan et al. (1985), Nalli et al. (2017)
Ganoderma sp. Ganoderic acids, riboflavin, ascorbic acid, mannitol, mannitol-alpha, alpha-trehalose, stearic acid, palmitic acid, lignoceric acid, n -nonadecanoic acid, behenic acid, tetracosanol, hentriacontane, choline, lycine Thrissur District, Kerala, Eastern Himalayas, Kashmir valley, Garhwal, South East Maharashtra Antimutagenic, anticarcinogenic, antiperoxidative activity, antiinflammatory activity Bhardwaj et al. (2016), Lakshmi et al. (2003), Jones and Kinghorn (2012)
Hippophae sp. Threonine, valine, methionine, leucine, lysine, trytophan, isoleucine, phenylalanine, ethyl 2-methylbutanoate, ethyl 3-methyl butanoate, alpha-tocopherol North-eastern Himalayas of India Cytoprotective, antistress, immunomodulatory, hepatoprotective, radioprotective, antiatherogenic, antitumor, antimicrobial, antiulcerogenic, tissue regeneration Gao et al. (2000), Geetha et al. (2003)
Nardostachys jatamansi E-2-methyl, 3-(5,9 dimethylbicyclo[4.3.0]nonen-9-yl)-2-propenoic acid, 2′,2′-dimethyl-3′-methoxy-3′,4′-dihydropyranocoumarin Uttaranchal, Himachal Pradesh, Arunachal Pradesh, Meghalaya (Grows at heights up to 5000 m in Eastern Himalayas, in Nepal, Bhutan and Sikkim) Palpitation of heart, intestinal tonic Indian Biodiversity Talks: Endangered medicinal herb Nardostachys Jatamansi is gradually vanishing from Uttarakhand
Origanum vulgare P-cymene, γ-terpinene, caryophyllene, spathulenol, germacrene-D, β-fenchyl alcohol, carvacrol, thymol, Γ-terpineol Uttaranchal, Himachal Pradesh (Native to Europe, naturalized in the Middle East) Volatile oil used as aromatic stimulant in rheumatism Origanum vulgare L. | Plants of the World Online | Kew Science; Mockute et al. (2001)
Polygonatum verticilatum α-Bulnesene, linalyl acetate, eicosadienoic, pentacosane, piperitone, docasane, diosgenin, santonin and calarene Himachal Pradesh, Uttaranchal, Meghalaya, Arunachal Pradesh (Found in Himalayas at height of 1800 to 3900 m) Fever, glactagogue, vitiated condition of pitta and vata, aphrodisiac, emollient Saboon et al. (2016)
Rhodiola sp. l-methionine, l-phenylalanine, l-lysine, l-leucine, and l-histidine, palmitoleic acid, oleic acid, linoleic acid Leh, Ladakh Adaptogenic, antifatigue, antidepressant, antioxidant, anti-inflammatory, antinoception, anticancer activities, prevent cardiovascular, neuronal, liver, skin disorders Dhar et al. (2013)
Valeriana wallichii Boryl isovalerianate, chatinine, formate, glucoside, isovalerenic acid, 1-camphene, 1-pinene, resins, terpincol and valerianine Uttaranchal, Himachal Pradesh (Distributed throughout drier parts of India) Alexiteric, cures epileptic seizures, head troubles, disease of eye, blood disease, suppression of urine, astringent carminative, hypnotic, aphrodisiac, pain in joint, disease of liver, clear the voice Devi and Rao (2014)
Valeriana sp. Bromazepam, clonazepam, diazepam, valerenic acid, beta-sitosterol, ursolic acid, 4,4′,8,8′-tetrahydroxy-3,3′-dimethoxyl-dibenzyl-ditetrahydrofuran and caryophyllene acide, valerane, naphthalene, linoleic acid, ethyl ester, myrtenyl acetate, ursolic acid, 4,4′,8,8′-tetrahydroxy-3, 3′-dimethoxyl-dibenzyl-ditetrahydrofuran Himachal Pradesh, it grows profusely in Bharmour division of Chamba, Kanda area of Karsog, and Chansil of Rohru forest division Treatment of habitual constipation, insomnia, epilepsy, neurosis, anxiety, diuretic, hepatoprotective, analgesic, and cytotoxic, antispasmodic, anticonvulsant, antiinflammatory Patočka and Jakl (2010), Saklani et al. (2012)
Withania somnifera Withanolides, withaferin A Uttaranchal, Himachal Pradesh. Rheumatism, consumption, coagulating milk, antioxidant, anxiolytic, adaptogen, memory enhancing, antiparkinsonian, antivenom, antiinflammatory, antitumor, immunomodulation, hypolipidemic, antibacterial, cardiovascular protection, sexual behavior Red Data Book; Wijnsma et al. (1985)

Some of the medicinal plants and herbs, such as Aconitum heterophyllum, Acorus calamus, Asparagus racemose, Atropa belladonna Linn., Bergenia ligulate, Cinchona ledgeriana, Colchicum luteum Baker, Cordyceps sp. , Curcuma sp. , Ganoderma sp. , Hippophae sp. , Nardostachys jatamansi, Origanum vulgare, Polygonatum verticilatum, Rhodiola sp. , Valeriana sp. , and Withania somnifera are unique in respect to their biological activities (Balakumbahan et al., 2010; Geetha et al., 2003; Hayes et al., 2008; Kaul, 1997; Mathews et al., 1990; Mishra et al., 2017a, b; Mockute et al., 2001; Patočka and Jakl, 2010; Rakhee et al., 2016; Saboon et al., 2016; Saha et al., 2016; Srimal, 2001; Wijnsma et al., 1985) .

Most of the bioactive compounds in the HA plants encompass secondary metabolites (as seen in Table 9.1). For instance, many HA herbal sources consist of substantial amounts of volatile organic compounds (VOCs), which are primarily responsible for imparting aroma and fragrance. Such compounds are used as chief ingredients in essential oils and oil-based healing formulations used to treat arthritis, muscle contractions, and sciatica. Several other secondary metabolites in these herbs are alkaloids, amino acids, fatty acids, flavonoids, glycosides, lignans, nucleotides, nucleoside, phenolic acids, phenols, proteins, resins, sterols, tannins, and terpenoids (Azmir et al., 2013; Ingle et al., 2017).

In light of the abundance of phytoconstituents in herbal sources and their varied bioactivities, it is essential to compile all the analytical techniques that enable isolation and characterization of these compounds. This compilation could further support their application as therapeutic agents.

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Toxicity and Protective Effects of African Medicinal Plants on the Spleen and Lung

Armel J. Seukep, … Victor Kuete, in Toxicological Survey of African Medicinal Plants, 2014

17.4.4 Medicinal Plants Screened Out of Africa with Beneficial Effect on the Lung

Although certain plants have toxic effects on the lungs, there are those which have beneficial effects. TCM contains numerous ingredients that they may be considered to have anti-lung cancer activity as well as serving as immunomodulators [59]. For examples, acetone extract of Angelica sinensis (Apiaceae) induced the activation of caspase 9/3 mediated by the suppression of Bcl-2 and cdk 4 expression in the A549, HT29 and J5DBTRG-05MG lung cancer cells lines. The ethanolic extract of Scutellaria barbata (Lamiaceae) activates caspase 3/7 [59]. Some Thai medicinal plants used as the ingredients of a Southern Thai traditional formula for cancer treatment were selected to test cytotoxicity activity against large cell lung carcinoma [60]. Other plants such as Bridelia ovata (Phyllanthaceae), Curcuma zedoaria (Zingiberaceae), Derris scandens (Fabaceae), Dioscorea membranacea (Dioscoreaceae), Nardostachys jatamansi (Valerianaceae), and Rhinacanthus nasutus (Acanthaceae) which displayed cytotoxic activity toward [lung carcinoma](https://www.sciencedirect.com/topics/ recommended smoking the dried entirely and

TL;dr

Maybe don’t handle sterile things and pour non sterile things on them before injecting into your body

I do hope you seek the proper medical care if this results in an injection

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Discourse handled formating that article copy paste shockingly well, I’m Impressed.

7 Likes

It sure did…

I’m fine it’s doing good just a tad bit bruised…

You wouldn’t know by now

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Naw maybe in the morning if it gets hot I’ll know…


I go thru like an ounce of pure essential oil a day…

I don’t mean to be a problem person but the video and some of these posts should probably be removed from the forum. I’d really feel bad if someone saw that video and replicated any of it, it’s a real health and safety issue…

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I feel like I’m on 4chan

10 Likes

There I deleted it Ben. You just didn’t want the Christian’s to see it. It’s ok they already seen it when it happened. If it’s really that deadly then you shouldn’t be doing it. If it brings condemnation then don’t do it. But what is death anyway oh death where is your sting oh hell where is your victory?

No we don’t want people seeing it thinking it’s the right way to do something and then giving themselves and infection or worse. It has 0 to do with religion and beliefs so don’t throw slanderous shit like that around at people.

You have no idea who may stumble across that video or information and the least we can do is keep it accurate to current understandings of medicine.

11 Likes

Ah damn…
I’m really sad I’m currently lacking time to properly answer this thread. Really sad.

I would have so many fun things to say to someone who claims to be

Oh this would be fun…
:smiling_imp:

I’m wondering how the hand is

it’s with jesus now :laughing:

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It’s fine


Just a lil swollen no infection I bumped it on the door yesterday evening that wasn’t so fun. I thought it may have popped out but it should still be in there it bled when I smacked it against the door. It’s in there the swelling went down enough to feel the implant.

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Apparently, rather suprisingly… it can take 2-7 days for a piercing infection to really manefest

Not sure if that’s 1:1 with a subdermal or not… but I wouldn’t consider yourself out of the woods yet

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When we culture blood for sepsis, it usually takes a minimum of 24-48 hours to grow something, and that’s in prime incubation conditions…

How is it today?